ProArgi-9+ - Clinically Studied. Scientifically Validated.

Scientists at the Hughes Center for Research and Innovation have made several remarkable discoveries on Synergy’s ProArgi-9+ formula, proving that ProArgi-9+ can do what l-arginine cannot do on its own. Following these discoveries, a provisional patent was filed in the United States to ensure that Synergy maintains exclusive rights to this iconic formula.

Numerous studies have shown the cardiovascular benefits of l-arginine. However, our preliminary in vitro and human studies showed that the unique combination of ingredients in our ProArgi-9+ formula enhances the effects of l-arginine within the body in several ways.


The body converts the amino acid l-arginine into nitric oxide to support healthy circulatory and cardiovascular function. Although l-arginine alone can increase the surrogate marker of saliva nitric oxide, this is a gradual process. In testing ProArgi-9+, it has been found that its formula significantly and rapidly increases the level of nitric oxide in the body.

The findings of this study are significant because other studies show that aging and a poor diet can affect the metabolic systems responsible for producing nitric oxide, causing them to work less effectively. Healthy nitric oxide levels are important for proper vasodilation, along with blood pressure, muscle, heart, and central nervous system function.


Previous studies have shown that l-arginine, by itself, has no significant effect on myeloperoxidase, an enzyme that inhibits nitric oxide production. Additionally, l-arginine has no significant influence on inhibiting the oxidation of LDL cholesterol. The Hughes Center’s preliminary study discovered that the unique combination of ingredients found in Synergy’s ProArgi-9+ effectively inhibited myeloperoxidase and helped to reduce the oxidation of LDL cholesterol.